John Grove stood out among the dozens of fatal drug overdose victims the Georgia Bureau of Investigation examined in November 2016.
It wasn’t just the 34-year-old’s hulking frame. At 6 feet 4 inches and nearly 270 pounds at autopsy, Grove’s muscular body showed few signs of the years he’d spent battling opioid addiction.
But when his toxicology test came back in January 2017, it revealed something unusual. There were no opioids in his system, nor were there cocaine or benzodiazepines, which are now responsible for the overwhelming majority of drug overdoses. Instead, Grove tested positive for a single substance: mitragynine, best known as the psychoactive ingredient of kratom, an herbal drug derived from the leaves of a Southeast Asian tree related to coffee.
And it was mitragynine that had caused Grove to collapse on the floor of his coworker’s bathroom and die, GBI concluded.
It was an odd and seemingly unprecedented determination. Scientists say there’s scant evidence that mitragynine causes fatal overdoses, and many kratom advocates claim that overdosing on the substance alone is impossible. Although authorities have come forward with reports of deaths supposedly related to kratom, all of the cases they’ve cited publicly have involved the presence of other, often more dangerous drugs, making it nearly impossible to discern kratom’s role in the fatalities.
But mitragynine was the only substance on Grove’s toxicology test. His death, listed as an…