The Amazing Health and Longevity Benefits of Vitamin C

Your badly mutated GULO (gulonolactone [L-] oxidase) gene has been robbing you of health all your life and limits your lifespan. It’s so badly mutated that the human variant is now called the GULOP pseudogene.

Clarifying GLO, GULO and GULOP
GLO is a protein enzyme called L-gulonolactone oxidase. L-gulonolactone oxidase catalyzes the ninth, critical step of ascorbic acid synthesis from glucose (blood sugar). The precursor L-gulono-1,4-lactone is a readily available product of glucose metabolism through the pentose phosphate cycle.

GULO is a gene that is called “L-gulonolactone oxidase gene.” A gene is NOT a protein. A gene is a sequence of DNA or RNA that codes for a molecule that has a function. In this case, GULO, is the gene that encodes for the enzyme GLO

GULOP is the human remnant of the gene that encodes L-gulonolactone oxidase in most other mammals. GULOP cannot generate a functional enzyme product and is therefore called a pseudogene.

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Here’s what you can do about it to improve your health and increase your lifespan.
Bill Sardi has been a guest of this column twice before, and has an overview of this subject scheduled for the October issue of the Journal of Orthomolecular Medicine. Specifically, we will chat with him about the latest research confirming the practical health and substantial longevity benefits of fully compensating for this defective pseudogene. The operative word here is “fully.” How much vitamin C is required to fully compensate for not having a working GULO gene? The paltry 60 milligrams that is the RDA or the several grams that animals make when they have a fully functioning GULO gene? What does the latest study suggest that…

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