Epigenetic modulation at birth – altered DNA-methylation in white blood cells after Caesarean section.
Acta Paediatr. 2009 Jul ;98(7):1096-9. PMID: 19638013
Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
AIM: Delivery by C-section (CS) has been associated with increased risk for allergy, diabetes and leukaemia. Whereas the underlying cause is unknown, epigenetic change of the genome has been suggested as a candidate molecular mechanism for perinatal contributions to later disease risk. We hypothesized that mode of delivery affects epigenetic activity in newborn infants.
METHODS: A total of 37 newborn infants were included. Spontaneous vaginal delivery (VD) occurred in 21, and 16 infants were delivered by elective CS. Blood was sampled from the umbilical cord and 3-5 days after birth. DNA-methylation was analyzed in leucocytes.
RESULTS: Infants born by CS exhibited higher DNA-methylation in leucocytes compared with that of those born by VD (p
CONCLUSION: DNA-methylation is higher in infants delivered by CS than in infants vaginally born. Although currently unknown how gene expression is affected, or whether epigenetic differences related to mode of delivery are long-lasting, our findings open a new area of clinical research with potentially important public health implications.
Article Published Date : Jul 01, 2009
Study Type : Human Study
Republished from: Green Med Info