Cannabis proven effective in treating neuropathic pain大麻證實能有效治療神經性疼痛
Debra Kain黛布拉kain
Smoked cannabis eased pain induced in healthy volunteers, according to a study by researchers at the University of California, San Diego (UCSD) Center for Medical Cannabis Research (CMCR.) However, the researchers found that less may be more.熏大麻緩解疼痛的誘導在健康志願者，根據一項研究結果在美國加州大學圣迭戈（加州大學聖地亞哥分校）為中心的醫療大麻的研究（ cmcr. ）不過，研究人員發現，少可能更多。
In the placebo controlled study of 15 subjects, a low dose of cannabis showed no effect, a medium dose provided moderate pain relief, and a high dose increased the pain response.在安慰劑對照研究了15個事項，低劑量的大麻表明，沒有任何影響，中等劑量提供中度疼痛救濟，和高劑量增加疼痛反應。 The results suggest a “therapeutic window” for cannabis analgesia, according to lead researcher Mark Wallace, MD, professor of anesthesiology at UCSD School of Medicine and Program Director for the UCSD Center for Pain Medicine.結果表明， “治療窗”為大麻鎮痛，根據研究的領導者馬克華萊士，醫學博士，教授，麻醉科在加州大學聖地亞哥分校醫學院的和計劃主任為加州大學聖地亞哥分校中心止痛藥。
The paper, to be published in the November issue of the journal Anesthesiology, is the second published study out of the CMCR.文件，將刊登在十一月期日刊麻醉，是第二次發表研究出來的cmcr 。 Headquartered at UCSD, the CMCR is collaboration between UCSD and UC San Francisco that was funded by a state-funded initiative in 1999 to rigorously study the safety and efficacy of medicinal cannabis in treating diseases.總部設在加州大學聖地亞哥分校， cmcr之間的合作是加州大學聖地亞哥分校和加州舊金山的資金由國家資助的倡議，在1999年的研究，嚴格的安全性和療效的藥用大麻在治療疾病。
The study used capsaicin, an alkaloid derived from hot chili peppers that is an irritant to the skin, to mimic the type of neuropathic pain experienced by patients with HIV/AIDS, diabetes or shingles – brief, intense pain following by a longer-lasting secondary pain.這項研究使用的辣椒素，一生物鹼來自熱辣椒這是一項刺激性皮膚，模仿類型的神經性疼痛的病人所經歷的與艾滋病毒/艾滋病，糖尿病或帶狀皰疹-簡言之，激烈的疼痛以下由一個持續時間更長中學痛苦。 The subjects were healthy volunteers who inhaled either medical cannabis or a placebo after pain was induced.受試者健康志願者吸入無論是誰的醫療大麻，或安慰劑後，疼痛的誘導。 The marijuana cigarettes were formulated under NIH supervision to contain either zero, two, four or eight percent delta-9-tetrahydrocannabinol (THC.)大麻香煙，制定保健院的監督下，以包含零，二，四或八％三角洲- 9 -四氫（ thc. ）
“Subjects reported a decrease in pain at the medium dose, and there was also a significant correlation between plasma levels of THC, the active ingredient in cannabis, and decreased pain,” said Igor Grant, MD, FRCP(C), professor and Executive Vice-Chair of the Department of Psychiatry, the director of the CMCR. “科目的報導減少了在疼痛在中等劑量，也有顯著相關的血漿水平的貨櫃碼頭處理費，活性成分在大麻，並減少疼痛，說： ”伊戈爾補助金，海事處， frcp （三） ，教授及行政人員副主席兼該部的精神病，總的cmcr 。 “Interestingly, the analgesic effect wasn’t immediate; it took about 45 minutes for the cannabis to have an impact on the pain,” he said. “有趣的是，鎮痛效果是不是即時;需時約45分鐘，為大麻有一個影響，對疼痛， ”他說。
The results, showing a medium-dose (4% THC by weight) of cannabis to be an effective analgesic, converged with results from the CMCR’s first published study, a paper by UCSF researcher Donald Abrams, MD published in the journal Neurology in February 2007.結果顯示，一個中等劑量（ 4 ％貨櫃碼頭處理費，按重量計算）的大麻是一種有效的鎮痛，融合的結果，從cmcr的首次出版，研究，一份文件，由ucsf司長艾布拉姆斯研究員，醫學博士發表在雜誌神經病學在2007年2月。 In that randomized placebo-controlled trial, patients smoking the same dose of cannabis experienced a 34% reduction in HIV-associated sensory neuropathy pain—twice the rate experienced by patients receiving a placebo.在這方面的隨機安慰劑對照試驗，病人吸煙相同劑量的大麻，經歷了34 ％ ，減少了艾滋病毒相關的感覺神經病疼痛增長率的兩倍所經歷的患者接受安慰劑。
“This study helps to build a case that cannabis does have therapeutic value at a medium-dose level,” said Grant. “這項研究有助於建立一宗大麻確有治療價值，在中等劑量的水平，說： ”補助金。 “It also suggests that higher doses aren’t necessarily better in certain situations – something also observed with other medications, such as antidepressants.” “它也表明，較高劑量的不一定是更好的，在某些情況下-一些還注意到，與其他藥物，如抗抑鬱藥” 。
The researchers stated that more and larger studies need to be conducted to measure the efficacy of cannabis, noting that medical marijuana could play an important role in treating patients who don’t respond well to the usual pain relievers or can’t tolerate drugs such as ibuprofen or opioids used for severe pain.研究人員指出，更多和更大的研究，需要進行衡量療效的大麻，注意到醫用大麻可以發揮重要的作用，在治療病人誰不回應，以及以慣常的痛苦，救援或無法忍受藥物，如布洛芬或阿片類藥物用於重度疼痛。
“The results of this study might help guide others doing clinical research into pain management,” said Wallace. “這項研究的結果可能會幫助指導別人做的臨床研究疼痛的管理，說： ”華萊士。
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Additional contributors to the study include Gery Schulteis, Ph.D., UCSD Department of Anesthesiology; J. Hampton Atkinson, MD, professor, and Deborah Lazzaretto, MS, UCSD HIV Neurobehavioral Research Center; Ian Abramson, Ph.D., UCSD Department of Mathematics and HIV Neurobehavioral Research Center; Tanya Wolfson, MA, UCSD Department of Family and Preventive Medicine; and Heather Bentley and Ben Gouaux, UCSD Center for Medicinal Cannabis Research.額外供款的研究，包括gery schulteis ，博士，加州大學聖地亞哥分校部麻醉的J.漢普頓阿特金森，醫學博士，教授，和德博拉lazzaretto ，質譜，加州大學聖地亞哥分校艾滋病毒神經研究中心;伊恩阿布拉姆森，博士，加州大學聖地亞哥分校署數學和艾滋病毒神經研究中心;坦尼婭沃爾夫森，馬，加州大學聖地亞哥分校署家庭和預防醫學;和石南本特利和Ben gouaux ，加州大學聖地亞哥分校中心，藥用大麻的研究。
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